Table 4.
Correlation between genotypes and risk for cancer in smokers or ex-smokers
| Genetic polymorphism | Cancer, n (%) | Control, n (%) | P | OR (95% CI) |
| NAT2a | ||||
| All | 65 | 87 | ||
| Mx/Mx | 40 (61.5) | 39 (44.8) | 0.09 | 1 |
| W/Mx | 22 (33.8) | 39 (44.8) | 1.82 (0.92-3.60) | |
| W/W | 3 (4.6) | 9 (10.3) | 3.08 (0.77-12.22) | |
| Slow | 40 (61.5) | 39 (44.8) | 0.06 | 1.97 (1.02-3.79) |
| Fast | 25 (38.5) | 48 (61.0) |
a
Homozygous individuals with genotype W/W, and heterozygote W/Mx, are grouped into fast acetylation phenotype, while homozygous Mx/Mx are grouped in slow acetylators. NAT2: N-acetyltransferase 2; OR: Odds ratio; 95% CI: Confidence interval.