Table 4.
Correlation between K-ras mutations and clinicopathological factors in colorectal cancer n (%)
| Terms | All | Wild type | Mutation type | P value |
| No. of patients | 118 | 77 (65.3) | 41 (34.7) | |
| Gender | 0.037 | |||
| Male | 71 | 51 (71.8) | 20 (28.2) | |
| Female | 47 | 26 (55.3) | 21 (44.7) | |
| Median age (yr) | 61.0 | 64.0 | 60.0 | 0.728 |
| Males | 65.0 | 65.0 | 65.5 | |
| Females | 60.0 | 60.5 | 58.0 | |
| Colorectal segment | 0.559 | |||
| Cecum | 5 | 1 (20.0) | 4 (80.0) | |
| Ascending colon | 23 | 17 (73.9) | 6 (26.1) | |
| Transversal colon | 8 | 4 (50.0) | 4 (50.0) | |
| Descending colon | 5 | 4 (80.0) | 1 (20.0) | |
| Sigmoid | 25 | 16 (64.0) | 9 (36.0) | |
| Rectum | 52 | 35 (67.3) | 17 (32.7) | |
| Differentiation | 0.761 | |||
| Poor | 17 | 12 (70.6) | 5 (29.4) | |
| Moderate | 42 | 25 (59.5) | 17 (40.5) | |
| Well | 59 | 40 (67.8) | 19 (32.2) | |
| UICC classification | 0.631 | |||
| I | 18 | 9 (50.0) | 9 (50.0) | |
| II | 48 | 37 (77.1) | 11 (22.9) | |
| III | 37 | 23 (62.2) | 14 (37.8) | |
| IV | 15 | 8 (53.3) | 7 (46.7) | |
| Bowel wall invasion (pT) | 0.120 | |||
| pT1 | 2 | 1 (50.0) | 1 (50.0) | |
| pT2 | 21 | 11 (52.4) | 10 (47.6) | |
| pT3 | 65 | 43 (66.2) | 22 (33.8) | |
| pT4 | 30 | 22 (73.3) | 8 (26.7) | |
| Lymph node metastasis (pN) | 0.585 | |||
| pN0 | 69 | 47 (68.1) | 22 (31.9) | |
| pN1-2 | 49 | 31 (63.3) | 18 (36.7) | |
| Distant metastasis (pM) | 0.301 | |||
| pM0 | 103 | 70 (68.0) | 33 (32.0) | |
| pM1 | 15 | 8 (53.3) | 7 (46.7) | |
UICC: Union for International Cancer Control.