Table 1. Genes differentially expressed in Rfx6 LOF microarray.
Genes have been sorted into categories based on the organ in which they are expressed. Fold change is relative to control samples, negative numbers represent down regulation in LOF tissue. NC, no change. NA, not applicable, the gene in question is not expressed that that time point. p < 0.05.
| unigene ID | fold change |
|||
|---|---|---|---|---|
| NF30 | NF40 | NF44 | ||
|
Pancreas | ||||
| amy2A | xl.21603 | NA | NA | −121.10 |
| Elas | xl.26506 | NA | −8.88 | −72.36 |
| DNase1-A | xl.932 | NC | NC | −27.66 |
| Cel | xl.24591 | NA | −10.85 | −23.57 |
| Sst | xl.13593 | NA | +2.30 | −15.00 |
| PDI | xl.80673 | NA | −13.94 | −11.46 |
| ctrb1 | xl.77315 | NA | −7.02 | −8.53 |
| Trypsin | xl.1858 | NA | NC | −4.94 |
| gcg-a | xl.193 | NA | NC | −4.51 |
| ins1-a | xl.817 | −2.21 | −5.84 | −4.03 |
| nm-a | xl.830 | NA | NC | −2.08 |
| Ptf1a | xl.29862 | NC | −3.62 | −3.77 |
| scg3-A | xl.15 | NA | NC | −2.10 |
| cela1 | xl.68767 | NA | −8.28 | NC |
| igf2-A | xl.23623 | −2.79 | −5.70 | NC |
| ctrl | xl.23397 | NA | −4.73 | NC |
| PP11-like | xl.82301 | NA | −4.69 | NC |
| hlxb9 | xl.55462 | NA | −3.17 | NC |
| cpa1 | xl.73839 | NA | −2.12 | NC |
| NeuroD | xl.26304 | −1.86 | NC | NC |
|
Stomach | ||||
| ATP4B | xl.26547 | NC | NC | −69.82 |
| ATP4A | xl.971 | NC | NC | −33.21 |
| tm4sf3 | xl.24486 | NC | NC | −10.26 |
| agr2 | xl.25847 | NC | +3.67 | −6.74 |
| Nkx6.2 | xl.55860 | NC | −6.92 | −3.98 |
| Sfrp2 | xl.15963 | NC | +2.16 | NC |
| PitX1 | xl.34927 | +1.75 | NC | NC |
|
Liver | ||||
| alb-b | xl.395 | NC | NC | −18.94 |
| adh8 | xl.53979 | NC | −5.52 | −2.24 |
| ca6 | xl.14854 | NC | −7.99 | NC |
| tm4sf4 | xl.53955 | NC | −5.21 | NC |
| ITIH3 | xl.5040 | NC | −4.48 | NC |
| fabp-a | xl.21513 | NC | −2.97 | NC |
| hnf4 | xl.1217 | +1.73 | NC | NC |
| adh6 | xl.48167 | NC | NC | +12.86 |
| arg1 | xl.1242 | NC | +2.16 | +16.96 |
|
Intestine | ||||
| villin1 | xl.81110, xl.24670 | NC | −4.21 | NC |
| crip1a | xl.48993 | NC | −3.01 | NC |
| xCad2 | xl.1358 | NC | NC | +3.08 |
| hand1 | xl.1098 | NC | NC | +3.47 |
| soat2 | xl.53150 | NC | NC | +6.64 |
| gamt | xl.11235 | NC | NC | +8.31 |
| darmin | xl.76581 | NC | NC | +8.59 |
|
Heart | ||||
| MLClv | xl.76359, xl.2576 | NC | −9.50 | −5.93 |
| MYH6 | xl.50419 | −5.73 | −3.95 | NA |
| tnni3 | xl.935 | NC | −2.93 | NA |
| tbx5 | xl.529 | −1.79 | −2.40 | NA |
| tnnc1 | xl.2228 | −3.97 | −2.28 | NA |
| tnnt2 | xl.23777 | −1.60 | −2.10 | NA |
| mlc1av-A | xl.11969 | −5.29 | −2.06 | NA |
| nkx2.5 | xl.22859 | −1.92 | −1.73 | NA |
| mlc2a | xl.76247 | −6.16 | NC | NA |
| MYH6 | xl.3161 | −6.14 | NC | NA |
| Mybpc3 | xl.2416 | −1.57 | NC | NA |
| nkx2.10-A | xl.623 | −1.57 | NC | NA |
| camk1 | xl.63784 | NC | +3.33 | +3.81 |
| MyHC | xl.80374 | NC | +1.79 | +3.88 |
|
Lung | ||||
| SFTPC | xl.55371 | NA | −15.60 | NA |
| cldn18 | xl.9841 | NA | −13.13 | NA |
| EST lung | xl.29467 | NA | −2.45 | NA |
| slc34a2 | xl.5596 | NA | −2.09 | NA |
| RSpo2 | xl.49496 | NA | −1.53 | NA |
|
Kidney | ||||
| tm4sf5 | xl.51559 | NC | −2.47 | NA |
| kcnj1 | xl.29882 | NC | +2.69 | NA |
| Gcm-1 | xl.16562 | NC | +3.13 | NA |
| UCP2 | xl.27125 | NC | +3.57 | NA |
| FoxC1 | xl.76079 | −1.75 | NC | NA |
| Ndrgl | xl.77767 | −1.62 | NC | NA |
| Nphsl | xl.14805 | −1.59 | NC | NA |
| Frzb2 | xl.619 | +1.71 | NC | NA |
| Hlbox1 | xl.1209 | +1.90 | NC | NA |
| tm6sf1 | xl.2482 | +2.17 | NC | NA |
| slc3a2 | xl.10583 | NC | NC | +2.34 |
| slc7a8 | xl.15844 | +2.11 | NC | +2.81 |
| slc43a2 | xl.5041 | NC | NC | +2.81 |
| PitX2A | xl.104 | NC | NC | +2.86 |
| Cln6 | xl.23306 | NC | NC | +4.93 |
| cldn4L1 | xl.21063 | NC | NC | +5.31 |
| xPox2 | xl.11968 | NC | +2.95 | +6.18 |