Table 1.
Average cross-sectional area (CSA) of whole nerve fibre, axon and myelin sheath from 6- and 12-month-old mstn+/+ and 6-, 12- and 24-month-old mstn−/− mice. All data are shown as mean ± SEM.
| Radial | Ischiatic | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Mstn+/+ | Mstn−/− | Mstn+/+ | Mstn−/− | ||||||
| Motor unit CSA (μm)2 | 6 months | 12 months | 6 months | 12 months | 24 months | 6 months | 12 months | 6 months | 12 months |
| Nerve fibre | 40.4 ± 1.4 | 27.1 ± 0.7 | 48.9 ± 1.2 | 40.6 ± 1.1* | 22.3 ± 0.5§# | 29.8 ± 0.7 | 26.8 ± 0.6 | 48.2 ± 0.9 | 31 ± 0.6* |
| Axon | 18.8 ± 0.8 | 10.9 ± 0.3 | 20.1 ± 0.6 | 17.1 ± 0.5* | 9.5 ± 0.3§# | 10.2 ± 0.3 | 9.7 ± 0.3 | 18.5 ± 0.5 | 11.8 ± 0.3* |
| Myelin sheath | 21.7 ± 0.7 | 16.2 ± 0.3 | 28.9 ± 0.7 | 23.5 ± 0.6* | 12.8 ± 0.3§# | 19.6 ± 0.4 | 17.1 ± 0.4 | 29.7 ± 0.5 | 19.2 ± 0.3* |
Radial nerve – nerve fibre: significant difference (P < 0.001) from *6-month-old mstn−/−, §6-month-old mstn−/− and # 12-month-old mstn−/− mice; axon: significant difference (P < 0.001) from *6-month-old mstn−/−, §6-month-old mstn−/− and #12-month-old mstn−/− mice; myelin sheath: significant difference (P < 0.001) from *6-month-old mstn−/−, §6-month-old mstn−/− and # 12-month-old mstn−/− mice.
Ischiatic nerve – nerve fibre: *significant difference (P < 0.001) from 6-month-old mstn−/−mice; axon: *significant difference (P < 0.001) from 6-month-old mstn−/−; myelin sheath: *significant difference (P < 0.001) from 6-month-old mstn−/−.