Table 5.
Studies on white bean extract and weight loss1
| Reference | Product | Design | BMI, kg/m2 | Dosage | Other intervention components | Δ Weight, kg | Significant difference between groups? |
| Thom (124) | Phaseolamin (white bean extract, 200 mg; inulin, 200 mg; Garcinia cambogia, 50 mg) | 12-wk RCT, double-blind (n = 20 active; n = 20 placebo) | Overweight + obese | 2 tablets immediately after each meal (breakfast, lunch, and dinner) | Prescribed 1200 kcal/d2 low-fat diet | Active: −3.5 ± 2.0 placebo: −1.3 ± 1.4 | Yes (34 completed; intent to treat analysis) |
| Udani et al. (125) | Phase 2 (previously sold as Phaseolamin) | 8-wk RCT, double-blind (n = 20 active; n = 19 placebo) | Obese | 1500 mg + 8 fl oz water with lunch and dinner | Prescribed high-fiber, low-fat diet; instructed to eat majority of CHO at lunch and dinner | Active: −1.7, placebo: −0.8 (SD not given) | No (intent to treat analysis) |
| Koike et al. (126) | Phaseolamin 1600 (white bean extract, 750 mg; clove, 200 mg; lysine, arginine, alanine, 20 mg each) | 8-wk open label, no control group (n = 10 active) | Normal weight + overweight | 2 capsules taken 30 min before lunch and dinner with water | Normal meals and exercise routine | Active: −1.8 (SD not given) | n/a |
| Opala et al. (127) | Nutrifin appeal PLUS (Finzelberh, GmbH & Co. KG) tablet 1: extracts of asparagus, green and black teas, guarana, mate, and kidney bean; tablet 2: extracts of kidney bean pods, Garcinia cambogia, chromium yeast | 12-wk RCT, double blind (n = 47 active; n = 51 placebo) | Overweight + obese | 2 tablets with each main meal (1 before and 1 after each meal) | Prescribed 1500 kcal/d;2 daily walking | Active: −2.0 ± 2.6 placebo: −1.5 ± 3.5; corrected for hours of exercise; active:−54 ± 73 g/h; placebo:−30.1 ± 68 g/h | No for kg; yes for g/h exercise; yes for percentage body fat (not shown) |
| Celleno et al. (128) | Phase 2 Starch neutralizer (Phaseolamin 2250) with 445 mg Phaseolus vulgaris extract, 0.5 mg chromium picolinate, calcium phosphate, vitamin B-3, and others | 30-d RCT, double-blind (n = 30 active; n = 20 placebo) | 5–15 kg overweight, mean BMI ∼26.0 ± 2 kg/m2 | 1 tablet/d before the main meal | Prescribed 2000–2250 kcal/d,2 carbohydrate rich | Active: −2.9 ± 1.6 placebo: −0.4 ± 0.4 | Yes |
| Udani and Singh (129) | Phase 2 Starch neutralizer (Phaseolamin 2250) supplied by Pharmachem Labs | 4-wk RCT, double-blind (n = 13 active; n = 12 placebo) | Normal weight, overweight, and obese | 2 x 500 mg capsules each at beginning of breakfast and lunch | 1800 kcal/d; provided breakfast and lunch, prescribed dinner; prescribed exercise 30 min x 4d/wk; behavior groups 1x/wk | Active: −2.7, placebo: −2.1; for highest CHO tertiles, active: −3.9, placebo: 0.7 (no SD given) | No overall, yes for highest CHO tertiles (no for 2 lower tertiles) |
| Wu et al. (130) | Phase 2 Starch neutralizer | 60-d RCT, double-blind (n = 51 active; n = 50 placebo) | Overweight + obese | 2 x 500 mg tablets 15 min before each meal (breakfast, lunch, and dinner) | No details provided | Active: −1.9 ± 0.2 placebo: −0.4 ± 0.1 | Yes |
1
RCT, randomized controlled trial.
2
1 kcal = 4.184 kJ.