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. Author manuscript; available in PMC: 2011 Feb 22.
Published in final edited form as: Oncogene. 2010 Jan 25;29(16):2337–2345. doi: 10.1038/onc.2009.516

Figure 5. PIK3CA mutants, but not AKT1 mutants, display increased sensitivity to rapamycin and the PI3K inhibitor LY294002.

Figure 5

Cells were seeded in triplicate wells on day 0 in medium containing 0.2 ng/ml EGF. Drugs or vehicle (DMSO) were added on days 1 and 4. Cells were harvested and counted on day 6. Values are shown as percentage of vehicle control cell number and represent averages of three independent experiments with standard deviations. * p=NS compared to MCF10A. ** p < 0.02 compared to MCF10A. ***p < 0.005 compared to MCF10A.