Table 2.

Linear Multivariate-Adjusted Correlates of Each Cognitive Domain as an Outcome^a

	LM Delayed Recall (n=885)		Verbal Fluency (n=888)		Trails B (n=873)
	β Estimate (SE)	P Value	β Estimate (SE)	P Value	β Estimate (SE)	P Value
Age, y	−0.3 (0.04)	<.001	−0.2 (0.1)	.001	3.3 (0.3)	<.001
School, y	0.9 (0.1)	<.001	1.1 (0.1)	<.001	−7.9 (0.8)	<.001
APOE4	−1.1 (0.7)	.11	1.2 (0.9)	.19	4.2 (5.8)	.47
Depression	1.1 (1.4)	.43	0.2 (1.9)	.94	8.1 (12.2)	.50
Antidepressant use	1.0 (0.7)	.13	1.0 (0.9)	.28	11.2 (5.7)	.05
LogAβ40:Aβ42	0.2 (0.4)	.62	0.5 (0.5)	.32	−2.1 (3.3)	.53
Depression × logAβ40:Aβ42	−1.9 (0.7)	.006	−1.8 (0.9)	.05	9.0 (5.7)	.12
Depression × logAβ40:Aβ42 by subgroup
MMSE score > 23 (n=652)b	−1.3 (0.4)	<.001	−1.6 (0.5)	<.001	+11.4 (3.1)	<.001
MMSE score ≤ 23 (n=233)b	−0.03 (0.5)	.95	−1.0 (0.6)	.10	+3.4 (3.1)	.24
LM Delayed Recall score > 14.6 (n=575)b	−0.7 (0.3)	.02	−1.6 (0.6)	.003	+11.9 (3.6)	.001
LM Delayed Recall score ≤ 14.6 (n=310)b	−0.4 (0.3)	.15	−0.9 (0.6)	.13	+7.1 (3.5)	.04

Abbreviations: Aβ₄₀, amyloid-β peptide 40; Aβ₄₂, amyloid-β peptide 42; LM, Logical Memory; MMSE, Mini-Mental State Examination.

^aAdditional variables adjusting for sex, race, creatinine level, diabetes mellitus, stroke, and cardiovascular disease are also included. Depression × logAβ₄₀:Aβ₄₂ is the interaction between depression (defined as Center for Epidemiological Studies Depression Scale score ≥ 16) and log₁₀ of plasma Aβ₄₀:Aβ₄₂ ratio. The same regression models were applied to subgroups according to cognitive scores after adjusting for age, school, APOE4, depression, antidepressant use, and logAβ₄₀:Aβ₄₂ in addition to sex, race, creatinine level, diabetes mellitus, stroke, and cardiovascular disease, and only the data on depression × logAβ₄₀:Aβ₄₂ are shown. Because Bonferroni correction was applied, P<.0167 is considered significant.

^bIncludes all of the above adjusting variables.