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. 2011 Mar;25(3):1048–1057. doi: 10.1096/fj.10-172635

Figure 3.

Figure 3.

Influence of estradiol on the survival of newborn neurons in the adult MOB. A) Representative images showing newly generated BrdU cells in the GrCL of the MOB, analyzed 4 wk after BrdU injections. Number of BrdU cells was decreased in WT-OVX-E2 and ArKO-OVX-E2 compared with WT-OVX and ArKO-OVX female mice. SEL, subependymal layer; Mi, mitral cell layer. B) Total number of BrdU+ cells in the MOB GrCL from the 6 experimental groups. C) Representative image of BrdU-NeuN double-labeled cell (arrow) under confocal microscopy. D) Percentage of BrdU-NeuN double-labeled cells counted in the GrCL of the MOB. OVX: WT, n = 6; ArKO, n = 6. Intact: WT, n = 4; ArKO, n = 4. OVX-E2: WT, n = 6; ArKO, n = 5. Values are expressed as means ± se. Scale bars = 60 μm (A); 6 μm (C). *P < 0.05, ***P < 0.005 vs. OVX; SP < 0.05 vs. WT; 2-way ANOVA followed by Fisher's post hoc test.