Table 1.
Characteristics of ovarian aging
Characteristics of ovarian aging | References |
---|---|
Varying initial oocyte numbers between individuals at birth/menarche | [11,12] |
Varying pace of follicular recruitment between individuals | [12] |
Decreasing pace of follicular recruitment with advancing age | [12] |
Decreasing numbers of follicles in folliculogenesis with advancing age | |
Increasingly poor egg quality with advancing age | [13-15] |
Due to decreasing follicles in folliculogenesis and poorer egg quality: | |
Decreasing embryo quality with advancing age | |
Decreasing spontaneous fecundity with advancing age | |
Decreasing oocyte numbers in IVF with advancing age | |
Decreasing embryo numbers in IVF with advancing age | |
Decreasing pregnancy rates with IVF | [7,8,15-18] |
Decreasing pregnancy rates with infertility treatments in general | [19] |
Increasing aneuploidy with advancing age* | [20] - [22] |
*Women with POA/OCPOI, though demonstrating all other characteristics of NOA, at prematurely young ages still demonstrate normal, age-appropriate aneuploidy rates [26]. While clinically in all other characteristics exhibiting characteristics of "older" ovaries, embryo quality will still be relatively good, allowing for excellent pregnancy chances with IVF