Table 2.
Studies of presurgical treatment with aromatase inhibitors compared with tamoxifen or chemotherapy
| Treatment | n | Clinical response (palpation/caliper) | P value versus tamoxifen |
| Anastrozole versus tamoxifen versus combination [68] | |||
| Anastrozole | 113 | 37% | 0.87 |
| Tamoxifen | 108 | 36% | |
| Anastrozole + tamoxifen | 109 | 39% | 0.61 |
| Anastrozole versus tamoxifen [69] | |||
| Anastrozole | 228 | 50.0 | 0.37 |
| Tamoxifen | 223 | 46.2 | |
| Letrozole versus tamoxifen [70] | |||
| Letrozole | 154 | 55% | <0.001 |
| Tamoxifen | 170 | 36% | |
| Exemestane versus tamoxifen [71] | |||
| Exemestane | 25 | 76.3% | 0.05 |
| Tamoxifen | 75 | 40.0% | |