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. 2011 Feb 4;12(1):20. doi: 10.1186/1465-9921-12-20

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Copyright ©2011 Fuchs et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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No effect of 1-oleoyl-2-acetyl-sn-glycerol (OAG) on normoxic vascular tone in TRPC6^-/-mouse lungs. The effect of OAG was investigated in isolated wild-type and TRPC6^-/-mouse lungs. The OAG-induced vasoconstriction is represented as the increase in pulmonary artery pressure (ΔPAP) during normoxic ventilation. OAG was applied in increasing doses every 25 min. Data are derived from n = 5 and n = 4 wild-type and TRPC6^-/-mice, respectively. * Significant differences compared to wild-type mice (p < 0.05).