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. 2011 Jan 18;8:6. doi: 10.1186/2045-8118-8-6

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Copyright ©2011 Gonzalez et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nestin immunoreactivity is decreased in the subependymal zone following Ecrg4 over-expression. A and C: Nestin immunoreactivity in rat subependymal zone. When examined under low (Panel A, 200×) or higher (Panel C, 400×) magnification, nestin immunoreactivity labeled neuroepithelial progenitor cells that were present and proliferating after the i.c.v. injection of Ad_GFPinto injured rat brains. Nestin was also detectable in the ependymal cell layer as denoted by arrows in the ventricle (v) where it co-localized with GFP positive cells. Blue = DAPI, Red = nestin, green and yellow = GFP in Ad_GFPpositive cells. B and D: Nestin immunoreactivity decreased in subependyma after AD_Ecrg4injection. There was decreased nestin staining that was readily observed in the subventricular zone of Ad_Ecrg4treated rat brains when examined under low (Panel B, 200×) or higher (Panel D, 400×) magnification. These are the same zones where BrdU incorporation was also decreased (see Figure 5). The ependymal cell layer is denoted by arrows in ventricle (v). Blue = DAPI, Red = nestin Scale bar = 20 μm.