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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Pharmacol Ther. 2011 Jan 20;130(1):26–37. doi: 10.1016/j.pharmthera.2011.01.004

Figure 1. MicroRNA Regulation of Key Proteins at the Dendrite.

Figure 1

From left: miR-134 suppresses LIMK1 translation at the synapse, while miR-132 suppresses p250GAP, an inhibitor of the Rho family GTPases. Acyl protein thioesterase 1 (APT1), an enzyme that regulates the palmitoylation status of synaptic proteins, is regulated by miR-138. In the dendritic shaft: RNA-binding proteins that regulate transport, stability and/or translation of mRNAs. Pumilio2 is regulated by miR-134, HuR is regulated by miR-519 and autosomal paralog of FMRP, FXR1P, is regulated by miRNAs 92b, 363 and 367. FMRP is present in microtubule-associated granules at the dendrite, and is shown associated with mRNAs and in a complex with microRNAs and precursor microRNAs. Dicer has also been reported in dendrites. Top of the spine, miR-125b regulates expression of the NR2A receptor, a component of the NMDA receptor.