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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Ageing Res Rev. 2010 Aug 10;10(2):191–200. doi: 10.1016/j.arr.2010.07.005

Figure 3.

Figure 3

Functional annotation of the AKT1 gene obtained from the UCSC genome browser (http://genome.ucsc.edu/; chromosome 14, base positions: 104,306,732-104,331,573) recently shown to harbor variations associated with human longevity [54]. The figure reveals the amount of information amassed about the AKT1 gene. The base locations and positions of coding regions and known mRNAs and spliced transcripts are depicted in the upper portions of the figure (e.g., `Refseq genes' and `Human ESTs'). The middle portions of the figure provide the locations of empirically identified regulatory elements in the region including enhancers and silencers obtained from protein-DNA binding studies involving different transcription factors (e.g., `CTCF' and `H3K4me1'). Cross species nucleotide conservation levels, the locations of known single nucleotide polymorphisms, and the locations of repeated sequences are provided in the lower portions of the figure.