Skip to main content
. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Oct 20;1812(8):893–908. doi: 10.1016/j.bbadis.2010.10.006

Figure 3. Model of three distinct transcriptional repression mechanisms for SHP.

Figure 3

SHP represses nuclear receptor (NR) or transcription factor (TF) mediated transactivation by competition for coactivator binding to NR (I), recruitment of SHP-associated corepressors (II), and inhibition of DNA binding (III). SHP can utilize these three inhibitory steps alternatively or sequentially in a cell type and target gene specific manner.