Figure 4. Integrated view of SHP as a central transcriptional coregulator in diverse physiological pathways in the liver.
Activation pathways are shown as broken blue arrows and inhibitory pathways are shown as broken red lines. FA, fatty acid; TG, triglyceride; VLDL, very low density lipoprotein; CYP7A1, cytochrome P450 enzyme cholesterol 7α-hydroxylase; G6P, glucose-6-phosphatase; HNF-4α, hepatocyte nuclear factor 4 α; JNK, c-jun N-terminal kinase; LRH-1, liver receptor homolog-1; LXR, liver X receptor; MTP, microsomal triglyceride transfer protein; PEPCK, phosphoenolpyruvate carboxykinase; PPARγ, peroxisome proliferator activated receptor γ; SHP, small heterodimer partner; SREBP-1c, sterol regulatory element binding protein-1c; WAT, white adipose tissue; and BAT, brown adipose tissue.
