Table 3.
SHP target genes and their function in physiology and disease
Tissue | Target gene | Function | Reference |
---|---|---|---|
Cholesterol and Bile acid metabolism | |||
Liver | ↓CYP7A1 | Bile acid synthesis | Goodwin et al., 2000 Lu et al., 2000 Boulias et al., 2005 |
↓CYP8B1 | Bile acid synthesis | Yang et al., 2002 Boulias et al., 2005 | |
↓CYP7B1 | Bile acid synthesis | Boulias et al., 2005 | |
↓BAT | Bile acid conjugation | Boulias et al., 2005 | |
↓BSEP | Bile acid transport | Boulias et al., 2005 | |
↓MDR2 | Bile acid transport | Boulias et al., 2005 | |
↓NTCP | Bile acid transport/uptake | Denson et al., 2001 Boulias et al., 2005 | |
↓SLC10A2 | Bile acid transport | Neimark et al., 2004 | |
↓ABCB11 | Bile acid export | Boulias et al., 2005 | |
↓ABCB4 | Bile acid export | Boulias et al., 2005 | |
↓ABCA1 | Cholesterol efflux | Brendel et al., 2002 Boulias et al., 2005 | |
↓APOA1 | Reverse cholesterol transport | Delerive et al., 2004 | |
↓CETP | Cholesteryl easter transfer | Luo et al., 2001 | |
↓SCARb1 | Cholesterol uptake | Boulias et al., 2005 | |
Lipid metabolism and Obesity | |||
Liver | ↑PPARγ | Lipogenesis | Nishizawa et al., 2002 Boulias et al., 2005 Huang et al., 2007 |
↑SREBP1C | Lipogenesis | Boulias et al., 2005 Huang et al., 2007 | |
↑CD36 | Long chain fatty acids uptake | Boulias et al., 2005 | |
↑FAS | Fatty acid and triglyceride biosynthesis | Boulias et al., 2005 Huang et al., 2007 | |
↑ACL | Fatty acid and triglyceride biosynthesis | Boulias et al., 2005 | |
↑ACC-1 | Fatty acid and triglyceride biosynthesis | Boulias et al., 2005 | |
↑SCD-1 | Fatty acid and triglyceride biosynthesis | Boulias et al., 2005 | |
↓MTP | Plasma lipoprotein secretion | Hirokane et al., 2004 Huang et al., 2007 Pan et al., 2010 | |
Brown adipose tissue | ↓UCP1 | Mitochondrial thermogenesis and biogenesis | Wang et al., 2005 |
↓PGC1α | Thermogenesis | Wang et al., 2005 | |
↓Dio2 | Thermogenesis | Wang et al., 2005 Tabbi-Anneni., 2010 | |
↑HSL | Lipolysis | Tabbi-Anneni., 2010 | |
↑LPL | Thermogenesis | Tabbi-Anneni., 2010 | |
↑β1AR | Mitochondrial thermogenesis and biogenesis | Tabbi-Anneni., 2010 | |
White adipose tissue | ↓SREBP1 ↓LPL |
Lipid accumulation | Tabbi-Anneni., 2010 |
Liver fibrosis | |||
Liver | ↓alpha1 (I) collagen | Fibrogenesis | Fiorucci et al., 2004 |
↓A-SMA | |||
↓TIMP-1 | Regulation of metalloproteinase activity | Fiorucci et al., 2005 | |
↓PAI-1 | Fibrogenesis | Chanda et al., 2009 | |
Glucose metabolism | |||
Liver | ↓PEPCK | Rate limiting gluconeogenic enzyme | Borgius et al.,2002 Park et al., 2007 Chanda et al., 2007 |
↓G6Pase | Regulate blood glucose levels | Kim et al., 2004 Lee et al., 2008 Chanda et al., 2009 | |
↓FBP1 | Gluconeogenesis | Yamagata et al., 2004 | |
↓LGK | Hepatic glucokinase | Kim et al., 2009 | |
Drug metabolism | |||
Liver | ↓CYP2B | Drug and hormone metabolism | Bae et al., 2004 |
↓CYB3A | Drug and hormone metabolism | Ourlin et al., 2003 | |
Cancer | |||
Liver | ↓CyclinD1 | Cell cycle | Zhang et al., 2008 |
↓Bcl2 | Apoptosis | Zhang et al., 2010 | |
Breast | ↓CYP19 | Estrogen production | Kovacic et al., 2004 |
Other | ↓Gli | Hedgehog signaling pathway | Kim et al., 2010 |
↓: inhibition; ↑: induction.