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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Oct 20;1812(8):893–908. doi: 10.1016/j.bbadis.2010.10.006

Table 3.

SHP target genes and their function in physiology and disease

Tissue Target gene Function Reference
Cholesterol and Bile acid metabolism

Liver ↓CYP7A1 Bile acid synthesis Goodwin et al., 2000 Lu et al., 2000 Boulias et al., 2005
↓CYP8B1 Bile acid synthesis Yang et al., 2002 Boulias et al., 2005
↓CYP7B1 Bile acid synthesis Boulias et al., 2005
↓BAT Bile acid conjugation Boulias et al., 2005
↓BSEP Bile acid transport Boulias et al., 2005
↓MDR2 Bile acid transport Boulias et al., 2005
↓NTCP Bile acid transport/uptake Denson et al., 2001 Boulias et al., 2005
↓SLC10A2 Bile acid transport Neimark et al., 2004
↓ABCB11 Bile acid export Boulias et al., 2005
↓ABCB4 Bile acid export Boulias et al., 2005
↓ABCA1 Cholesterol efflux Brendel et al., 2002 Boulias et al., 2005
↓APOA1 Reverse cholesterol transport Delerive et al., 2004
↓CETP Cholesteryl easter transfer Luo et al., 2001
↓SCARb1 Cholesterol uptake Boulias et al., 2005

Lipid metabolism and Obesity

Liver ↑PPARγ Lipogenesis Nishizawa et al., 2002 Boulias et al., 2005 Huang et al., 2007
↑SREBP1C Lipogenesis Boulias et al., 2005 Huang et al., 2007
↑CD36 Long chain fatty acids uptake Boulias et al., 2005
↑FAS Fatty acid and triglyceride biosynthesis Boulias et al., 2005 Huang et al., 2007
↑ACL Fatty acid and triglyceride biosynthesis Boulias et al., 2005
↑ACC-1 Fatty acid and triglyceride biosynthesis Boulias et al., 2005
↑SCD-1 Fatty acid and triglyceride biosynthesis Boulias et al., 2005
↓MTP Plasma lipoprotein secretion Hirokane et al., 2004 Huang et al., 2007 Pan et al., 2010
Brown adipose tissue ↓UCP1 Mitochondrial thermogenesis and biogenesis Wang et al., 2005
↓PGC1α Thermogenesis Wang et al., 2005
↓Dio2 Thermogenesis Wang et al., 2005 Tabbi-Anneni., 2010
↑HSL Lipolysis Tabbi-Anneni., 2010
↑LPL Thermogenesis Tabbi-Anneni., 2010
↑β1AR Mitochondrial thermogenesis and biogenesis Tabbi-Anneni., 2010
White adipose tissue ↓SREBP1
↓LPL
Lipid accumulation Tabbi-Anneni., 2010

Liver fibrosis

Liver ↓alpha1 (I) collagen Fibrogenesis Fiorucci et al., 2004
↓A-SMA
↓TIMP-1 Regulation of metalloproteinase activity Fiorucci et al., 2005
↓PAI-1 Fibrogenesis Chanda et al., 2009
Glucose metabolism
Liver ↓PEPCK Rate limiting gluconeogenic enzyme Borgius et al.,2002 Park et al., 2007 Chanda et al., 2007
↓G6Pase Regulate blood glucose levels Kim et al., 2004 Lee et al., 2008 Chanda et al., 2009
↓FBP1 Gluconeogenesis Yamagata et al., 2004
↓LGK Hepatic glucokinase Kim et al., 2009

Drug metabolism

Liver ↓CYP2B Drug and hormone metabolism Bae et al., 2004
↓CYB3A Drug and hormone metabolism Ourlin et al., 2003
Cancer
Liver ↓CyclinD1 Cell cycle Zhang et al., 2008
↓Bcl2 Apoptosis Zhang et al., 2010
Breast ↓CYP19 Estrogen production Kovacic et al., 2004
Other ↓Gli Hedgehog signaling pathway Kim et al., 2010

↓: inhibition; ↑: induction.