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. Author manuscript; available in PMC: 2012 Feb 2.

Published in final edited form as: J Am Chem Soc. 2011 Feb 2;133(4):808–819. doi: 10.1021/ja104983t

(a) RDC histogram for IL1β-S1, -S2 and -S3. (b) RDC histogram for IL1β-R1, -R2 and -R3. (c) RDC histogram for IL1β-L1, -L2 and –L3. (d) . Estimated values of $D_{a}^{N H}$ and R are obtained by nonlinear least-squares optimization of equations $D_{z z}^{N H} = 2 D_{a}^{N H}$ ; $D_{y y}^{N H} = - D_{a}^{N H} (1 + 1.5 R)$ , $D_{x x}^{N H} = - D_{a}^{N H} (1 - 1.5 R)$ and $R = \frac{D_{r}^{N H}}{D_{a}^{N H}}$ . The values of D_zz, D_yy and D_xx were measured from the histograms of the RDCs for IL1β-LBT by taking the extreme high and low values such that $∣ D_{z z}^{N H} ∣ > ∣ D_{y y}^{N H} ∣ \geq ∣ D_{x x}^{N H} ∣$ . D_xx corresponds to the most populated value in the histogram of the RDCs.⁷⁸,⁷⁹