Table 3.
Patient characteristics and prevalence of select risk factors in chronic pancreatitis patients (stratified by etiology groups) in the North American Pancreatitis Study 2
| Variable | Etiology Group (n) | p-value | ||||
|---|---|---|---|---|---|---|
| Alcohol (240) | Non-Alcohol (145) | Idiopathic (154) | Alcohol vs. Non-alcohol | Alcohol vs. Idiopathic | Idiopathic vs. Non-alcohol | |
| Patient characteristics | ||||||
| Mean age (± SD) | 50.9±12.0 | 46.5±17.6 | 50±18.5 | 0.01 | 0.62 | 0.09 |
| Males (%) | 168 (70) | 51 (35.2) | 64 (41.6) | <0.001 | <0.001 | 0.31 |
| White Race (%) | 192 (80) | 127 (88.2) | 138 (89.6) | 0.05 | 0.02 | 0.84 |
| History of acute pancreatitis (%) | 151 (63.2) | 100 (69.4) | 94 (61.4) | 0.26 | 0.81 | 0.19 |
| Prior cholecystectomy (%) | 88 (36.7) | 80 (55.2) | 70 (45.5) | 0.001 | 0.10 | 0.12 |
| Prevalence of select risk factors | ||||||
| At-risk drinking (%) | 155 (64.6) | 8 (5.5) | 8 (5.2) | <0.001 | <0.001 | 0.89 |
| Ever smoker (%) | 222 (92.9) | 71 (49.7) | 89 (58.6) | <0.001 | <0.001 | 0.16 |
| Maximum BMI (%) | 0.21 | 0.10 | 0.70 | |||
| Normal/Low | 69 (33) | 36 (27.3) | 26 (21.7) | |||
| Overweight | 69 (33) | 44 (33.3) | 49 (40.8) | |||
| Obese | 71 (34) | 52 (39.4) | 45 (37.5) | |||
| Current BMI >30 (%) | <0.001 | 0.005 | 0.18 | |||
| Normal/Low | 166 (69.7) | 65 (46.1) | 80 (54.1) | |||
| Overweight | 50 (21) | 52 (36.9) | 48 (32.4) | |||
| Obese | 22 (9.2) | 24 (17) | 20 (13.5) | |||
| Renal disease or failure (%) | 4 (1.7) | 10 (6.9) | 8 (5.2) | 0.02 | 0.09 | 0.71 |
| Phenotypic characteristics | ||||||
| Exocrine insufficiency (%) | 70 (30.8) | 30 (22.2) | 40 (28.6) | 0.10 | 0.73 | 0.29 |
| Endocrine insufficiency (%) | 68 (29.2) | 32 (22.7) | 38 (26.4) | 0.21 | 0.64 | 0.56 |
| Pancreatic duct dilation/stricture (%) | 145 (60.4) | 100 (69.0) | 87 (56.5) | 0.11 | 0.51 | 0.04 |
| Calcifications (%) | 159 (66.2) | 56 (38.6) | 83 (53.9) | <0.001 | 0.02 | 0.01 |
| Pseudocyst(s) (%) | 92 (38.3) | 28 (19.3) | 20 (13.0) | <0.001 | <0.001 | 0.18 |
| Common bile duct dilation/stricture (%) | 52 (21.7) | 17 (11.7) | 13 (8.4) | 0.02 | 0.001 | 0.45 |
At-risk drinking = Individuals who met criteria for at-risk drinking using the TWEAK questionnaire in the months before getting pancreatitis. The presence of renal disease or failure was extracted from the patient questionnaire.
Maximum BMI = Calculated based on the patient's self-reported highest weight (ever).
Current BMI = Calculated based on the patient's self-reported weight at the time of enrollment into NAPS2
BMI (body-mass index) (kg/m2) categories: normal/low: <25; overweight: 25–30; obese: ≥30