Table 2.

CCTA Diagnostic Accuracy Study Quality and Internal Validity, as Assessed by Modified QUADAS Tool

QUADAS item	Response % (N = 42)
	Yes	No	Unclear
Spectrum representative of disease risk	29	66	5
Clear selection criteria	73	19	8
Referent likely to classify CAD	90	0	10
Limited time between diagnostic and referent	81	2	17
Avoid partial verification bias	83	10	7
Avoid differential verification bias	94	4	2
Avoid incorporation bias	98	0	2
Avoid test review bias	71	2	27
Avoid diagnostic review bias	54	8	38
Avoid clinical review bias	67	29	4
Non-diagnostic results reported	65	33	2
Withdrawals explained	33	63	4
Established cut-off for significant stenosis	96	2	2
Observer variation reported	23	77	0
Data presented for appropriate subgroups	90	2	8
True CAD prevalence reported	79	21	0

“Response %” is based on the proportion of studies meeting criteria for each item

CCTA: Coronary computed tomographic angiography

QUADAS: Quality assessment of diagnostic accuracy studies

CAD: Coronary artery disease