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. 2011 Mar 2;100(5):1325–1334. doi: 10.1016/j.bpj.2011.01.037

Figure 4.

Figure 4

TEM images of cationic and anionic peptides. TEM images were obtained from solutions in which spectral evidence indicated the formation of β-sheet assemblies. (A) SEVI: [peptide] = 1.33 mM, [NaCl] = 150 mM (in phosphate-buffered saline); (B) K2(FKFE)2: [peptide] = 0.9 mM, [NaCl] = 100 mM, fibril diameter = 2.9 ± 0.5 nm; (C) K4(FKFE)2: [peptide] = 0.9 mM, [NaCl] = 200 mM, spotted onto a nickel grid, fibril diameter = 3.4 ± 0.6 nm. (D) K2(ChaKChaE)2: [peptide] = 0.3 mM, [NaCl] = 0 mM, fibril diameter = 5.9 ± 0.9 nm; (E) K4(ChaKChaE)2: [peptide] = 0.3 mM, [NaCl] = 100 mM, spotted onto a nickel grid, fibril diameter = 5.0 ± 0.8 nm; (F) E2(FKFE)2: [peptide] = 0.3 mM, [NaCl] = 0 mM, at pH 7, fibril diameter = 3.2 ± 0.6 nm; (G) E4(FKFE)2: [peptide] = 0.3 mM, [NaCl] = 1 M, at pH 7, fibril diameter = 4.5 ± 0.6 nm; (H) E2(ChaKChaE)2: [peptide] = 0.3 mM, [NaCl] = 0 mM, at pH 7, 2.8 ± 0.5 nm; (I) E4(ChaKChaE)2: [peptide] = 0.3 mM, [NaCl] = 0 mM, at pH 7, fibril diameter = 3.2 ± 0.4 nm.