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Observed and predicted values of percentage changes from baseline in a median absolute neutrophil count (ANC) and b median alanine aminotransferase (ALT) levels. Simulation of percentage changes from baseline in median ANC/ALT with induction dose at 6 μg/(kg week) from weeks 1 to 8, and dose modification of peginterferon α-2b to 3, 2, 1, or 0 μg/(kg week) during weeks 9–12
