Fig. 2.

p53 and mitochondrial respiration. Basal p53 levels transcriptionally activate synthesis of cytochrome oxidase 2 (SCO2) and apoptosis-inducing factor (AIF), which support the function of mitochondrial respiratory chain complexes I, III & IV and acts directly on complex IV subunit 1. p53 transcriptionally activates glutaminase 2 (GLS2), which catalyses the conversion of glutamine to glutamate. p53 regulates FAO via transcriptional activation of guanidinoacetate aminotransferase (GAMT), and possibly by other mechanisms