Table 3.
Measures of impulsivity after deep brain stimulation or dopaminergic pharmacotherapy in patients with Parkinson's disease.
| Study | Outcome measures | PD + DBS | PD + DA | P value | |
|---|---|---|---|---|---|
| Halbig et al. | Barratt impulsiveness Scale; mean (SD) | “on” treatment | 44.97 (17.29) | 36.11 (17.29) | 0.04 |
| Czernecki et al. | Stimulus reward association learning (number of trials)*; mean (SEM) | “on” treatment | 19.2 (3.9) | 22.6 (5.6) | 0.37 (group)** |
| “off” treatment | 23.1 (4.6) | 28.8 (4.8) | |||
| Reversal* (number in 30 trials); mean (SEM) | “on” treatment | 1.6 (0.2) | 1.3 (0.2) | 0.48 (group)** | |
| “off” treatment | 1.3 (0.2) | 1.3 (0.2) | |||
| Extinction* (last error); mean (SEM) | “on” treatment | 8.1 (1.1) | 14.2 (2.5) | 0.13 (group)** | |
| “off” treatment | 10.5 (1.6) | 11.8 (1.9) | |||
| Gambling task; mean (SEM) | “on” treatment | 25.4 (10.2) | 13.4 (6.9) | 0.39 (group)** | |
| “off” treatment | 19.4 (9.6) | 14.2 (6.4) | |||
In all measures (except the Barratt impulsiveness scale and the extinction test), lower scores indicate higher impulsivity.
∗Tasks described in Rolls et al. [17]∗∗ANOVA results of P-value of group effect (patients on stimulation versus patients on medication)
Abbreviations. PD + DBS: patients with Parkinson's disease who underwent deep brain stimulation surgery; PD + DA: patients with Parkinson's disease treated with dopaminergic medications (levodopa and/or dopamine agonists); “on” treatment: on medication and stimulation (if applicable) on the time of assessment; “off” treatment: off medication and stimulation.