Step	Solution	Rate (ml/h)	Time	Dose (mg)	Cumulative dose (mg)
1	A	2	15	0·01	0·01
2	A	5	15	0·025	0·035
3	A	10	15	0·05	0·085
4	A	20	15	0·1	0·185
5	B	5	15	0·25	0·435
6	B	10	15	0·5	0·935
7	B	20	15	1·0	1·935
8	B	40	15	2·0	3·935
9	C	10	15	5	8·935
10	C	20	15	10	18·935
11	C	40	15	20	38·935
12	C	75	184·4	461·065	500
			Total time 5·82 h		Total dose 500 mg

Reproduced with permission from Lee CW et al. [96]. Solution A: 0·02 mg/ml [total volume 250 ml; total dose 5 mg]; Solution B: 0·2 mg/ml [total volume 250 ml; total dose 50 mg]; Solution C: 2 mg/ml [total volume 250 ml; total dose 500 mg].