Table 1.

Effects of transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) on spleen index and thymus index.

Groups	Dose (mg/kg)	Spleen index (mg/g)	Thymus index (mg/g)
Normal	–	2·09 ± 0·11	1·01 ± 0·17
Model	–	3·30 ± 0·31**	1·51 ± 0·19**
TACI-Ig	0·7	3·00 ± 0·26	1·48 ± 0·50
	2·1	2·52 ± 0·11***	1·48 ± 0·14
	6·3	2·67 ± 0·23***	1·22 ± 0·29
rhTNFR : Fc	2·8	3·00 ± 0·45	1·41 ± 0·48
IgG-Fc	6·3	3·15 ± 0·18	1·34 ± 0·13

Spleen index and thymus index of adjuvant arthritis (AA) model group increased significantly compared to normal group (P < 0·01). After administration of TACI-Ig (2·1 and 6·3 mg/kg), spleen index of AA rats decreased significantly (P < 0·01) and administration of TACI-Ig (0·7, 2·1 and 6·3 mg/kg) had no significant influence on thymus index of AA rats. Data are expressed as mean ± standard deviation from 10 animals for each group.

^**P < 0·01 versus normal group;

*P < 0·05;

^***P < 0·01 versus model group. rhTNFR: recombinant human tumour necrosis factor-α receptor.