Table 1.

Evaluation of acute dextran sulphate sodium (DSS)-induced colitis in BALB/c and SCID mice orally treated with Parabacteroides distasonis components.

Mouse strain	Experimental group	Colon length (cm)	Disease activity index	Histological grade	Serum haptoglobin (g/l)
BALB/c	PBS (control)	5·97 ± 0·46	3·13 ± 0·74	2·05 ± 0·58	1·49 ± 0·64
	mPd	6·77 ± 0·40**	1·77 ± 0·97**	1·36 ± 0·51*	0·38 ± 0·35*
	cPd	5·96 ± 0·42	3·47 ± 0·53	2·14 ± 0·69	0·84 ± 0·80
	DNA	7·32 ± 0·44**	1·57 ± 0·61**	1·01 ± 0·36**	0·05 ± 0·06**
	LPS	6·70 ± 0·36**	2·07 ± 1·30*	1·68 ± 0·43	0·36 ± 0·08**
	mPd without DSS	8·97 ± 0·40**	0·00 ± 0·00**	0·15 ± 0·13**	0·00 ± 0·01**
	PBS without DSS	9·26 ± 0·41**	0·00 ± 0·00**	0·10 ± 0·20**	0·02 ± 0·01**
SCID	PBS (control)	6·20 ± 0·55	4·00 ± 0·00	2·69 ± 0·49	Not done
	mPd	6·13 ± 0·63	3·89 ± 0·17	2·58 ± 0·46	Not done

Data are representative of one experiment. Similar results were obtained from three independent experiments. Values are expressed as means ± standard deviation from six to 10 mice per group. One-way analysis of variance with Dunnett's multiple comparison test (in BALB/c mice) or unpaired Student's t-test [severe combined immunodeficient (SCID) mice] were used to evaluate differences between experimental groups and phosphate-buffered saline (PBS)-treated controls. cPd: cytoplasmic fraction of P. distasonis lysate; mPd: membranous fraction of P. distasonis; LPS: lipopolysaccharide (

^*P < 0·05;

^**P < 0·01).