Table 2.

Evaluation of chronic dextran sulphate sodium (DSS)-induced colitis in BALB/c mice orally treated with Parabacteroides distasonis components.

Experimental group	Colon length (cm)	Disease activity index	Histological grade	Serum haptoglobin (g/l)
PBS	6·25 ± 0·37	3·08 ± 0·39	1·56 ± 0·35	0·91 ± 0·60
mPd	6·79 ± 0·51*	2·25 ± 0·56*	1·59 ± 0·28	0·20 ± 0·15**
cPd	6·46 ± 0·40	3·08 ± 0·39	1·63 ± 0·31	0·09 ± 0·05**
LPS	6·96 ± 0·34*	2·82 ± 0·65	1·51 ± 0·37	0·06 ± 0·02**
PBS without DSS	9·22 ± 0·83**	0·73 ± 0·26**	0·14 ± 0·14**	0·01 ± 0·01**
mPd without DSS	8·89 ± 0·60**	0·45 ± 0·40**	0·32 ± 0·20**	0·01 ± 0·01**

Data are representative of one experiment. Similar results were obtained from two independent experiments. Values are expressed as means ± standard deviation (10 mice per group). One-way analysis of variance with Dunnett's multiple comparison test was used to evaluate differences between experimental groups and phosphate-buffered saline (PBS)-treated controls (

^*P < 0·05;

^**P < 0·01). mPd: membranous fraction of P. distasonis; cPd: cytoplasmic fraction of P. distasonis lysate; LPS: lipopolysaccharide.