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Effect of sodium valproate with CCBs in MES- and PTZ-induced seizures
| Drugs and dose (mg/kg) | MES No. of mice protected n=12 (% protection) | PTZ No. of mice protected n=12 (% protection) |
|---|---|---|
| Sodium valproate (300 mg/kg) | 6 (50.00) | 6 (50.00) |
| Sodium valproate (300 mg/kg) and cinnarizine (30 mg/kg) | 12 (100.00)* | 10 (83.33)* |
| Sodium valproate (300 mg/kg) and nifedipine (5 mg/kg) | 10 (83.33)* | 12 (100.00)* |
P<0.05 when compared to sodium valproate
