Table 3.
Selected Literature in Preclinical Therapeutic Application of Schwann Cells
| Disease | Animal Host | Year | Reference | Publication Title |
|---|---|---|---|---|
| Spinal cord trauma | ||||
| Hemitransected cord | mouse | 1995 | 254 | Reinnervation of peripheral nerve segments implanted into the hemisected spinal cord estimated by transgenic mice |
| Transected dorsal column | rat | 1994 | 214 | Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord |
| Transected cord | mouse and rat | 1981 | 2 | Influences of the glial environment on the elongation of axons after injury: Transplantation studies in adult rodents |
| rat | 1995 | 408 | Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord | |
| Contusion | cat | 1982 | 403 | Reconstruction of the contused cat spinal cord by the delayed nerve graft technique and cultured peripheral non-neuronal cells |
| rat | 1993 | 249 | Syngeneic grafting of adult rat DRG-derived Schwann cells to the injured spinal cord | |
| Photochemical lesion | rat | 1994 | 46 | Transplantation of purified populations of Schwann cells into lesioned adult rat spinal cord |
| Compression injury | rat | 1987 | 389 | Chronic regenerative changes in the spinal cord after cord compression injury in rats |
| Diphtheria toxin injection | cat | 1980 | 133 | Remyelination by cells introduced into a stable demyelinating lesion in the central nervous system |
| Lysolecithin injection | mouse | 1981 | 88 | Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord |
| X-irradiation with ethidiumbromide injection | cat | 1985 | 36 | The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system |
| rat | 1987 | 37 | Schwann cell remyelination of CNS axons following injection of cultures of CNS cells into areas of persistent demyelination | |
| Optic nerve injury | rat | 1995 | 135 | Schwann cells and the regrowth of axons in the mammalian CNS: A review of transplantation studies in the rat visual system |
| Monocular deprivation | rat | 1994 | 296 | Schwann cells transplanted in the lateral ventricles prevent the functional and anatomical effects of monocular deprivation in the rat |
| Parkinson’s disease | ||||
| MPTP | mouse | 1990 | 75 | Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice |
| monkey | 1994 | 67 | Peripheral nerve-dopamine neuron co-grafts in MPTP-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems | |
| 6-OHDA-induced hemiparkinsonism | monkey | 2004 | 407 | Therapeutic study of autologous Schwann cells’ bridge graft into the brain of hemiparkinsonian monkey |
| Brain trauma | ||||
| Septal-hippocampal lesions | rat | 1985 | 187 | Transplants of Schwann cell cultures promote axonal regeneration in the adult mammalian brain |
| Unilateral fornix transaction | rat | 1996 | 362 | Reconstruction of transected postcommissural fornix in adult rat by Schwann cell suspension grafts |
| Brain stem injury | rat | 2003 | 390 | Schwann cells transplantation promoted and the repair of brain stem injury in rats |