Table 8.
Selected Literatures in Preclinical Therapeutic Application of Amniotic Epithelial Cells
| Disease | Animal Host | Year | Reference | Publication Title |
|---|---|---|---|---|
| Parkinson’s disease | rat | 2000 | 167 | Human amniotic epithelial cells produce dopamine and survive after implantation into the striatum of a rat model of Parkinson’s disease: A potential source of donor for transplantation therapy |
| 6-OHDA lesion | rat | 2003 | 168 | Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions |
| MPTP | mouse | 2008 | 183 | Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice |
| Mucopolysaccharidosis type VII | mouse | 2001 | 186 | Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in mucopolysaccharidosis type VII mice |
| Brain ischemia | rat | 2001 | 280 | Amniotic epithelial cells transform into neuron-like cells in the ischemic brain |
| mouse | 2007 | 316 | Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice | |
| MCAo | rat | 2008 | 230 | Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model |
| Spinal cord trauma | ||||
| Transection | monkey | 2003 | 335 | Role of human amniotic epithelial cell transplantation in spinal cord injury repair research |
| rat | 2006 | 405 | Transplantation of human amniotic epithelial cells improves hind-limb function in rats with spinal cord injury | |
| Peripheral nerve injury | ||||
| Sciatic nerve defects | rat | 2004 | 85 | Bridging rat sciatic nerve defects with the composite nerve-muscle autografts wrapped with human amnion matrix membrane |
| Brain injury | rat | 2006 | 241 | Treatment of traumatic brain injury in rats with transplantation of human amniotic cells |