Table 1.
TNM Staging of Gallbladder Cancer (AJCC)
| Tumor | Node | Metastasis | |
|---|---|---|---|
| Stage 0 | Tis | N0 | M0 |
| Stage I | T1 | N0 | M0 |
| Stage II | T2 | N0 | M0 |
| Stage III | T1 | N1 | M0 |
| T2 | N1 | M0 | |
| T3 | N0-1 | M0 | |
| Stage IVA | T4 | N2 | M0 |
| Stage IVB | T1-4 | N0-2 | M1 |
Tis, Carcinoma in situ; T1, tumor invades mucosa or muscle layer; T2, tumor invades perimuscular connective tissue; T3, tumor perforates the serosa and/or directly invades 1 adjacent organ; T4, tumor extends more than 2 cm into the liver and/or into 2 or more adjacent organs; N0, no regional lymph node metastasis; N1, metastasis in cystic duct, peri choledochal and/or hilar lymph nodes; N2, metastasis in peripancreatic, periduode- nal, periportal, celiac, and/or mesenteric lymph nodes; M0, no distant metastasis; M1, distant metastasis.