Fig. 1.

Controlling cell fate through internalized biodegradable particles. (A) Schematic illustration of functionalizing cells with biodegradable particles to generate cells with internalized particles. (B) The encapsulated agent can control the cell and neighboring microenvironment in three distinct ways. The release of the agent can control the fate of the (i) particle-carrying cell through intracrine-like signaling, (ii) neighboring cell, through paracrine-like signaling, (iii) and distant cells through endocrine-like signaling.