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. Author manuscript; available in PMC: 2012 Jan 7.
Published in final edited form as: Cell Stem Cell. 2011 Jan 7;8(1):106–118. doi: 10.1016/j.stem.2010.12.003

Figure 4.

Figure 4

Dynamic copy number changes over long-term passage. (A) BAF and LRR plots of chromosome 15 for early and late passage samples of the MIZ4 hESC line. The early passage plots show normal autosomal BAF and LRR distributions, while the late passage plots indicate that a subpopulation of the cells have a duplication of chromosome 15. (B) BAF and LRR plots of the X chromosome for early and late passage samples of the UC06 hESC line. There is a subtle widening of the band of heterozygous SNPs in the BAF plot for the early passage sample, which has separated into two distinct bands in the BAF plot for the late passage sample, indicating that the small subpopulation of cells carrying a duplication of the X chromosome in the early passage population has outcompeted the cells without the duplication over long-term passage.