Table 3.
Antigenic variants in variable regions of PorA during persistent carriage in individual carriers
| Volunteer | PorA type (time point[s]a) |
Type of alteration | |
|---|---|---|---|
| Initial | Subsequent | ||
| V56 | P1.7,30-4 (November) | P1.7,30-3 (December) | 9 CTA to 8 CTA |
| V99 | P1.7-2,13-1 (February) | P1.7-2,13 (May) | 4 ACT to 5 ACT |
| V117 | P1.5-1,10-1 (November, December) | P1.5-1,10-29 (February, May) | C to T |
a
Time points indicate when each strain was isolated from a particular carrier. Note that volunteer V99 was a noncarrier at the November and December time points, such that the initial clone was first detected in February, and that V56 underwent clonal replacement in May (see Table 4).