Table 4.
Status of capsule, PorA, and FetA types during clonal replacement in individual carriers
| Volunteer | Clone (time point[s])a |
Altered antigen(s)b | |
|---|---|---|---|
| Initial | Replacement | ||
| V54 | Y:P1.21,16:F3-7:ST8510 (November, December, February) | W-135:P1.18-1,3:F4-1:ST1158 (May) | All |
| V63 | Y:P1.21,16:F3-7:ST8510 (November) | B:P1.7,30:F4-1:ST6604 (December) | All |
| V138 | Y:P1.21,16:F3-7:ST1466 (November, December, February) | 29E:P1.5,2:F1-7:ST1383 (May) | All |
| V64 | Y:P1.5-1,10-1:F1-3:ST767 (November, December, February) | NG:P1.17,9:F1-82:ST823 (May) | Minor FetA |
| V82 | Y:P1.5-1,10-1:F1-3:ST767 (November) | 29E:P1.21-7,16:F5-8:ST1157 (December, February, May) | All |
| V124 | Y:P1.5-1,10-1:F1-3:ST767 (November, December, February) | NG:P1.7,30:F4-1:ST6604 (May) | All |
| V140 | 29E:P1.5-1,10-26:F5-5:ST6798 (November, December, February) | B:P1.22,14:F5-5:ST213 (May) | Not FetA |
| V115 | 29E:P1.5,2:F1-7:ST1383 (November, December) | Y:P1.21,16:F3-7:ST1466 (February) | All |
| V120 | 29E:P1.5,2:F1-7:ST1383 (November) | Y:P1.5-1,10-1:F1-3:ST767 (May) | Minor PorA VR1 and FetA |
| V137 | 29E:P1.5,2:F1-7 (November) | B:P1.5,2:F1-5:ST8511 (February) | Not PorA and minor FetA |
| V50 | 29E:P1.5,2:F1-7:ST1383 (December, February) | Y:P1.5-1,10-10:F4-1:ST1655 (May) | Minor PorA VR1 |
| V70 | 29E:P1.21-7,16:F5-36:ST1157 (February) | NG:P1.7,30:F1-2:ST53 (May) | All |
| V226 | B:P1.22,14:F5-5:ST213 (December) | NG:P1.18,25-14:Fnull:ST823 (February, May) | All |
| V199 | B:P1.22,9:F5-5:ST283 (November, February) | W-135:P1.18-1,3:F4-1:ST2638 (May) | All |
| V192 | W-135:P1.18-1,3:F4-1:ST1617 (November) | NG:P1.18-1,3:F3-6:ST3808 (December, February, May) | Not PorA |
| V56 | NG:P1.7,30-3:F1-2:ST53 (November, December) | 29E:P1.5,2:F1-7:ST1383 (May) | Minor FetA |
| V206 | NG:P1.22,1:F1-1:ST103 (November) | 29E:P1.5-1,10-8:F3-6:ST254 (December, February) | All |
| V145 | B:P1.22,14:F5-5:ST213 (November) | 29E:P1.21-7,16:F5-36:NDc (December) | Minor FetA |
a
Time points indicate when each strain was isolated from a particular carrier. Note that volunteers V50, V70, and V226 were noncarriers in November, while the absence of data for other time points indicates that a volunteer was not subject to sampling.
b
All = capsule, PorA, and FetA. See Materials and Methods for a definition of minor and major variations in PorA and FetA.
c
ND, not determined.