Table 4.

Trends in susceptibility of Candida bloodstream infection isolates to anidulafungin and micafungin: comparison of ECVs with the CLSI clinical breakpoint MICs

Antifungal agent and species (ECV [μg/ml])	Yr	No. of isolates tested	MIC (μg/ml)		% of MICs
			Range	Mode	>ECV	>2 μg/ml
Anidulafungin
C. albicans (0.12)	2004	1,120	0.007–0.25	0.03	0.9	0.0
	2005	1,045	0.007–0.25	0.03	0.1	0.0
	2006	869	0.007–1	0.03	0.2	0.0
	2007	749	0.007–0.12	0.03	0.0	0.0
	2008	650	0.007–0.12	0.03	0.0	0.0
	2009	560	0.007–2	0.015	0.4	0.0
C. glabrata (0.25)	2004	252	0.03–1	0.06	0.4	0.0
	2005	291	0.03–4	0.12	0.7	0.3
	2006	238	0.015–0.5	0.06	0.4	0.0
	2007	239	0.015–0.25	0.06	0.0	0.0
	2008	247	0.015–2	0.06	1.2	0.0
	2009	175	0.015–2	0.06	1.8	0.0
C. tropicalis (0.12)	2004	211	0.007–2	0.03	2.8	0.0
	2005	227	0.007–2	0.03	1.8	0.0
	2006	203	0.007–0.12	0.03	0.0	0.0
	2007	208	0.007–0.12	0.03	0.0	0.0
	2008	161	0.007–0.25	0.03	0.6	0.0
	2009	124	0.007–0.12	0.015	0.0	0.0
C. krusei (0.12)	2004	53	0.015–0.12	0.03	0.0	0.0
	2005	59	0.015–0.5	0.06	1.7	0.0
	2006	34	0.03–0.12	0.03	0.0	0.0
	2007	94	0.03–0.25	0.03	1.1	0.0
	2008	40	0.03–0.12	0.03	0.0	0.0
	2009	35	0.015–0.06	0.03	0.0	0.0
C. parapsilosis (4)	2004	284	0.5–4	2	0.0	3.9
	2005	243	0.5–4	2	0.0	12.1
	2006	209	0.25–4	2	0.0	7.2
	2007	220	0.25–4	2	0.0	6.8
	2008	236	0.015–4	2	0.0	5.9
	2009	162	0.015–4	1	0.0	3.7
Micafungin
C. albicans (0.03)	2004	943	0.007–0.12	0.015	7.1	0.0
	2005	1,045	0.007–0.06	0.015	1.3	0.0
	2006	869	0.007–0.5	0.015	0.7	0.0
	2007	749	0.007–0.25	0.015	0.9	0.0
	2008	650	0.007–0.06	0.015	0.2	0.0
	2009	560	0.007–1	0.015	2.2	0.0
C. glabrata (0.03)	2004	200	0.007–0.25	0.015	3.0	0.0
	2005	291	0.007–1	0.015	3.1	0.0
	2006	238	0.007–0.03	0.015	0.0	0.0
	2007	239	0.007–0.06	0.015	0.8	0.0
	2008	247	0.007–2	0.015	1.6	0.0
	2009	175	0.007–2	0.015	1.2	0.0
C. tropicalis (0.12)	2004	176	0.007–1	0.03	2.3	0.0
	2005	227	0.007–1	0.03	0.4	0.0
	2006	203	0.007–0.25	0.015	2.0	0.0
	2007	208	0.007–0.06	0.015	0.0	0.0
	2008	161	0.007–0.12	0.03	0.0	0.0
	2009	124	0.007–0.25	0.015	0.8	0.0
C. krusei (0.12)	2004	42	0.015–0.25	0.06	2.4	0.0
	2005	59	0.015–0.12	0.06	0.0	0.0
	2006	34	0.03–0.25	0.06	11.8	0.0
	2007	94	0.015–0.25	0.06	1.1	0.0
	2008	40	0.03–0.12	0.06	0.0	0.0
	2009	35	0.03–0.25	0.06	5.7	0.0
C. parapsilosis (4)	2004	243	0.25–2	1	0.0	0.0
	2005	243	0.25–2	1	0.0	0.0
	2006	209	0.25–2	1	0.0	0.0
	2007	220	0.06–2	1	0.0	0.0
	2008	236	0.015–2	1	0.0	0.0
	2009	162	0.015–8	1	3.1	6.2