Table 4.
Antifungal agent and species (ECV [μg/ml]) | Yr | No. of isolates tested | MIC (μg/ml) |
% of MICs |
||
---|---|---|---|---|---|---|
Range | Mode | >ECV | >2 μg/ml | |||
Anidulafungin | ||||||
C. albicans (0.12) | 2004 | 1,120 | 0.007–0.25 | 0.03 | 0.9 | 0.0 |
2005 | 1,045 | 0.007–0.25 | 0.03 | 0.1 | 0.0 | |
2006 | 869 | 0.007–1 | 0.03 | 0.2 | 0.0 | |
2007 | 749 | 0.007–0.12 | 0.03 | 0.0 | 0.0 | |
2008 | 650 | 0.007–0.12 | 0.03 | 0.0 | 0.0 | |
2009 | 560 | 0.007–2 | 0.015 | 0.4 | 0.0 | |
C. glabrata (0.25) | 2004 | 252 | 0.03–1 | 0.06 | 0.4 | 0.0 |
2005 | 291 | 0.03–4 | 0.12 | 0.7 | 0.3 | |
2006 | 238 | 0.015–0.5 | 0.06 | 0.4 | 0.0 | |
2007 | 239 | 0.015–0.25 | 0.06 | 0.0 | 0.0 | |
2008 | 247 | 0.015–2 | 0.06 | 1.2 | 0.0 | |
2009 | 175 | 0.015–2 | 0.06 | 1.8 | 0.0 | |
C. tropicalis (0.12) | 2004 | 211 | 0.007–2 | 0.03 | 2.8 | 0.0 |
2005 | 227 | 0.007–2 | 0.03 | 1.8 | 0.0 | |
2006 | 203 | 0.007–0.12 | 0.03 | 0.0 | 0.0 | |
2007 | 208 | 0.007–0.12 | 0.03 | 0.0 | 0.0 | |
2008 | 161 | 0.007–0.25 | 0.03 | 0.6 | 0.0 | |
2009 | 124 | 0.007–0.12 | 0.015 | 0.0 | 0.0 | |
C. krusei (0.12) | 2004 | 53 | 0.015–0.12 | 0.03 | 0.0 | 0.0 |
2005 | 59 | 0.015–0.5 | 0.06 | 1.7 | 0.0 | |
2006 | 34 | 0.03–0.12 | 0.03 | 0.0 | 0.0 | |
2007 | 94 | 0.03–0.25 | 0.03 | 1.1 | 0.0 | |
2008 | 40 | 0.03–0.12 | 0.03 | 0.0 | 0.0 | |
2009 | 35 | 0.015–0.06 | 0.03 | 0.0 | 0.0 | |
C. parapsilosis (4) | 2004 | 284 | 0.5–4 | 2 | 0.0 | 3.9 |
2005 | 243 | 0.5–4 | 2 | 0.0 | 12.1 | |
2006 | 209 | 0.25–4 | 2 | 0.0 | 7.2 | |
2007 | 220 | 0.25–4 | 2 | 0.0 | 6.8 | |
2008 | 236 | 0.015–4 | 2 | 0.0 | 5.9 | |
2009 | 162 | 0.015–4 | 1 | 0.0 | 3.7 | |
Micafungin | ||||||
C. albicans (0.03) | 2004 | 943 | 0.007–0.12 | 0.015 | 7.1 | 0.0 |
2005 | 1,045 | 0.007–0.06 | 0.015 | 1.3 | 0.0 | |
2006 | 869 | 0.007–0.5 | 0.015 | 0.7 | 0.0 | |
2007 | 749 | 0.007–0.25 | 0.015 | 0.9 | 0.0 | |
2008 | 650 | 0.007–0.06 | 0.015 | 0.2 | 0.0 | |
2009 | 560 | 0.007–1 | 0.015 | 2.2 | 0.0 | |
C. glabrata (0.03) | 2004 | 200 | 0.007–0.25 | 0.015 | 3.0 | 0.0 |
2005 | 291 | 0.007–1 | 0.015 | 3.1 | 0.0 | |
2006 | 238 | 0.007–0.03 | 0.015 | 0.0 | 0.0 | |
2007 | 239 | 0.007–0.06 | 0.015 | 0.8 | 0.0 | |
2008 | 247 | 0.007–2 | 0.015 | 1.6 | 0.0 | |
2009 | 175 | 0.007–2 | 0.015 | 1.2 | 0.0 | |
C. tropicalis (0.12) | 2004 | 176 | 0.007–1 | 0.03 | 2.3 | 0.0 |
2005 | 227 | 0.007–1 | 0.03 | 0.4 | 0.0 | |
2006 | 203 | 0.007–0.25 | 0.015 | 2.0 | 0.0 | |
2007 | 208 | 0.007–0.06 | 0.015 | 0.0 | 0.0 | |
2008 | 161 | 0.007–0.12 | 0.03 | 0.0 | 0.0 | |
2009 | 124 | 0.007–0.25 | 0.015 | 0.8 | 0.0 | |
C. krusei (0.12) | 2004 | 42 | 0.015–0.25 | 0.06 | 2.4 | 0.0 |
2005 | 59 | 0.015–0.12 | 0.06 | 0.0 | 0.0 | |
2006 | 34 | 0.03–0.25 | 0.06 | 11.8 | 0.0 | |
2007 | 94 | 0.015–0.25 | 0.06 | 1.1 | 0.0 | |
2008 | 40 | 0.03–0.12 | 0.06 | 0.0 | 0.0 | |
2009 | 35 | 0.03–0.25 | 0.06 | 5.7 | 0.0 | |
C. parapsilosis (4) | 2004 | 243 | 0.25–2 | 1 | 0.0 | 0.0 |
2005 | 243 | 0.25–2 | 1 | 0.0 | 0.0 | |
2006 | 209 | 0.25–2 | 1 | 0.0 | 0.0 | |
2007 | 220 | 0.06–2 | 1 | 0.0 | 0.0 | |
2008 | 236 | 0.015–2 | 1 | 0.0 | 0.0 | |
2009 | 162 | 0.015–8 | 1 | 3.1 | 6.2 |