Table 5.

Variation in susceptibility of Candida species to posaconazole over a 9-year period (2001 to 2009)^a

Species (ECV [μg/ml])	Yr	No. of isolates tested	MIC (μg/ml)		% of MICs > ECV
			Range	Mode
C. albicans (0.06)	2001	1,062	0.007–0.5	0.015	1.1
	2002	1,273	0.007–0.5	0.015	1.2
	2003	1,291	0.007–2	0.015	0.8
	2004	1,120	0.007–0.5	0.015	3.0
	2005	1,045	0.007–1	0.015	1.6
	2006	869	0.007–0.06	0.015	0.0
	2007	749	0.007–0.5	0.03	1.6
	2008	650	0.007–1	0.03	3.8
	2009	560	0.007–0.5	0.03	3.2
C. glabrata (2)	2001	302	0.03–>8	0.5	0.9
	2002	344	0.03–>8	0.25	2.6
	2003	326	0.03–>8	0.5	5.8
	2004	252	0.06–>8	0.25	7.5
	2005	292	0.007–>8	0.25	4.4
	2006	238	0.03–>8	0.25	1.7
	2007	239	0.06–>8	0.5	3.7
	2008	247	0.06–>8	0.5	3.6
	2009	175	0.06–>8	0.5	4.5
C. parapsilosis (0.25)	2001	265	0.015–0.5	0.12	1.1
	2002	320	0.007–0.5	0.06	0.3
	2003	410	0.007–0.5	0.06	2.7
	2004	302	0.007–0.5	0.06	0.7
	2005	265	0.015–0.5	0.06	0.4
	2006	230	0.007–0.25	0.03	0.0
	2007	220	0.007–0.25	0.03	0.0
	2008	236	0.007–1	0.06	0.4
	2009	162	0.007–0.25	0.06	0.0
C. tropicalis (0.12)	2001	186	0.015–0.25	0.12	5.9
	2002	289	0.007–0.5	0.03	1.0
	2003	285	0.007–0.25	0.06	1.1
	2004	211	0.015–2	0.03	3.8
	2005	227	0.007–0.5	0.06	3.1
	2006	203	0.007–1	0.015	2.0
	2007	208	0.007–0.5	0.03	2.0
	2008	162	0.015–0.25	0.06	1.2
	2009	124	0.015–0.12	0.03	0.0
C. krusei (0.5)	2001	53	0.12–1	0.25	1.9
	2002	74	0.06–0.5	0.25	0.0
	2003	66	0.03–1	0.25	3.0
	2004	53	0.015–1	0.25	1.9
	2005	59	0.06–0.5	0.25	0.0
	2006	34	0.015–0.25	0.12	0.0
	2007	94	0.015–0.5	0.25	0.0
	2008	40	0.06–0.5	0.25	0.0
	2009	35	0.03–1	0.25	2.9

^aResults obtained after 24 h of incubation.