Figure 3. Plasma volumes determined from haematocrit.

A, ANP caused a significant loss of plasma water as measured from the increase in haematocrit at the end of the ANP infusion. Rolipram significantly attenuated the loss of plasma fluid. *Significant increase relative to control (t test); **significant decrease relative to ANP alone. B, mice pre-treated with rolipram retain infused albumin solution to the same extent as mice lacking the receptor to ANP in endothelium (see Discussion (Sabrane et al. 2005)).