Table 4.
Contribution of tissue to total albumin clearance
| Tissue weight (g) | Control | ANP | Rolipram | Rolipram + ANP | |
|---|---|---|---|---|---|
| Muscle | 12 | 27.6 | 35.7 | 19.2 | 20.7 |
| Skin | 6 | 38.0 | 86.4 | 22.8 | 31.9 |
| Kidney | 0.3 | 40.5 | 58.5 | 32.4 | 31 |
| Heart | 0.1 | 4.5 | 5.1 | 4.1 | 3.3 |
| GI | 0.5 | 23.7 | 41.1 | 28.9 | 37.8 |
| Total | 134.3 | 226.8 | 107.4 | 124.7 |
All values are μl (30 min) −1 (30 g body wt) −1. To calculate total tissue clearance by adding the contributions from each tissue take the mean 30 min clearance on a dry weight basis (Table 1 or 2), divide by wet/dry ratio (2.5 for skin and 4 for all other tissues) to give clearance on a per gram wet weight basis, then multiply by average tissue weight.