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. Author manuscript; available in PMC: 2011 Feb 23.
Published in final edited form as: Nat Neurosci. 2010 May 23;13(6):664–666. doi: 10.1038/nn.2560

Figure 3. Cortical DNA methylation is required for remote memory.

Figure 3

a, Intra-ACC infusions of 5-aza (N’s = 14, 13; F(1, 26) = 11.48), zeb (N’s = 7, 7; F(1, 13) = 21.07) or RG108 (N’s = 10, 10; F(1, 19) = 5.17) 30d after training disrupted remote fear memory. * P ≤ 0.05. b, DNMTi interfered with CS-induced CaN methylation (N’s = 6, 6; F(1,11) = 8.96) and normalized CaN transcript levels (t8 = 8.34, * P ≤ 0.001). c, Intra-ACC infusions of DNMTi 1d after training had no effect on fear memory (N’s = 7, 8; F(1,14) = 0.81, P > 0.05). Same animals also expressed normal fear memory 30 days later (F(1,12) = 0.26, P > 0.05). Experiment was repeated in absence of a test at 2d to confirm lack of damage to ACC. Again, infusions had no effect on fear memory (N’s = 7, 8; F(1,14) = 0.81, P > 0.05). Error bars indicate s.e.m.