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. Author manuscript; available in PMC: 2011 Feb 23.
Published in final edited form as: J Med Genet. 2010 Aug 15;47(11):745–751. doi: 10.1136/jmg.2009.076703

Figure 2.

Figure 2

Testing for the 4qA161 haplotype by differential digestion with Hpy188I and Hpy188III. Genomic DNAs and human-rodent somatic cell hybrids (GM14193, GM11687, and GM10926 containing chr4, chr4, and chr10, respectively; Coriell Institute) were analysed for overlapping Hpy188I (purple) or Hpy188III (blue) sites. Whether one or two 4qA161 alleles were present was subsequently determined by the sequencing assay. GM11448 and GM10115 containing chr4 were negative for 4qA161 (not shown) (A). The Hpy188I or Hpy188III sites are indicated for the forward strand in the SNP-rich region of 4qA161, the other main 4qA alleles, and the predominant 10qA allele (B).