Table 2. Fold change in gene expression in the P10 compared to the adult cornea.
Genes differentially expressed in the adult versus postnatal day 10 cornea. A total of 50 genes over expressed in the P10 cornea appear as positive numbers and 12 over expressed in the adult cornea as negative numbers.
| Symbol | Gene | Function | *Fold change |
|---|---|---|---|
| 5730454B08Rik | RIKEN cDNA 5730454B08 gene | Unknown | 3.8 |
| Anpep | Alanyl (membrane) aminopeptidase | Proteolysis (angiogenesis, antimicrobial) | 2.6 |
| Cd14 | CD14 antigen | Innate immune response | 2.6 |
| Cd63 | CD63 antigen | Growth regulation | 2.8 |
| Cdkn1c | Cyclin-dependent kinase inhibitor 1C (P57) | Cell growrth regulation | 9.0 |
| Clic4 | Chloride intracellular channel 4 (mitochondrial) | Apoptosis (p53 mediated) | 3.4 |
| Col14a1 | Procollagen, type XIV, alpha 1 | ECM (collagen fibril organization) | 6.4 |
| Col1a1 | Procollagen, type I, alpha 1 | ECM (fibrillar collagen) | 2.8 |
| Col1a2 | Procollagen, type I, alpha 2 | ECM (fibrillar collagen) | 3.8 |
| Col3a1 | Procollagen, type III, alpha 1 | ECM (fibrillar collagen) | 55.6 |
| Col4a1 | Procollagen, type IV, alpha 1 | ECM (basement membrane collagen) | 4.6 |
| Col4a2 | Procollagen, type IV, alpha 2 | ECM (basement membrane collagen) | 3.2 |
| Col6a2 | Procollagen, type VI, alpha 2 | ECM cell adhesive | 2.5 |
| Col8a1 | Procollagen, type VIII, alpha 1 | ECM (cell adhesive collagen) | 6.2 |
| Cri1 | CREBBP/EP300 inhibitory protein 1 | Transcription Factor | 3.1 |
| Ctsk | Cathepsin K | Proteolysis | 2.8 |
| Cyp2a4 | Cytochrome P450, family 2, subfamily a, polypeptide 4 | Electron transport | 3.3 |
| Ddr2 | Discoidin domain receptor family, member 2 | (collagen-receptor for dendritic cells | 5.0 |
| Eln | Elastin | ECM (tissue elastomeric properties) | 6.3 |
| Emp2 | Epithelial membrane protein 2 | Cell proliferation/apoptosis | 3.1 |
| Fbn1 | Fibrillin 1 | ECM (connective tissue microfibril) | 3.0 |
| Fgf2 | Fibroblast growth factor receptor 2 | Angiogenesis | 3.2 |
| Fndc1 | Fibronectin type III domain containing 1 | ECM (cell adhesive) | 2.4 |
| Fstl1 | Follistatin-like 1 | Cell proliferation/differentiation | 4.6 |
| Ggh | Gamma-glutamyl hydrolase | Proteolysis (exipeptidase) | 2.8 |
| Gpc3 | Glypican 3 | Cell growth and/or maintenance | 2.8 |
| Gtl2 | Maternally expressed untranslated mRNA | Unknown | 4.4 |
| H0D4S114 | DNA segment, human D4S114 | Unknown | 3.8 |
| Ifitm3 | Interferon induced transmembrane protein 3 | Immune response | 2.8 |
| Igfbp4 | Insulin-like growth factor binding protein 4 | Cell growth regulation | 2.7 |
| Itm2a | Integral membrane protein 2A | Cell differentiation | 5.0 |
| Krt1-19 | Keratin complex 1, acidic, gene 19 | Cytoskeleton (intermediate filament) | 3.9 |
| Ltbp4 | Latent transforming growth factor beta binding protein 4 | TGF beta signaling | 3.2 |
| Mfap2 | Microfibrillar-associated protein 2 | Connective tissue microfibril | 4.3 |
| Nrp1 | Neuropilin | Chemorepulsive axon guidance | 4.0 |
| Peg3 | Paternally expressed 3 | Transcription factor neuronal death via p53/Bax | 8.4 |
| Pitpnb | Phosphotidylinositol transfer protein, beta | Lipid-mediated signaling | 3.6 |
| Postn | Periostin, osteoblast specific factor | Collagen fubrl assembly (Akt/PKB ) | 2.9 |
| Ppic | Peptidylprolyl isomerase C | Protein folding | 4.1 |
| Prss11 | Protease, serine, 11 (Igf binding) | regulates IGF release and availability | 3.2 |
| Pten | Phosphatase and tensin homolog | Cell cycle regulator (tumor suppressor) | 7.1 |
| Rest | RE1-silencing transcription factor | Unknown | 4.9 |
| Rnase4 | Ribonuclease, RNase A family 4 | Monocyte differentiation | 3.2 |
| Sema4a | Semaphorin 4A | Chemorepulsive axon guidance | 4.3 |
| Serpinh1 | Serine/cysteine proteinase inhibitor, clade H, member 1 | Proteinase inhibitor | 3.1 |
| Sf3b1 | Splicing factor 3b, subunit 1 | RNA processing/gene regulation | 5.5 |
| Sfrs7 | Splicing factor, arginine/serine-rich 7 | RNA processing/gene regulation | 3.3 |
| Slc1a4 | Solute carrier family 1member 4 | Glutamate/neutral amino acid transporter | 2.8 |
| Sparcl1 | SPARC-like 1 (mast9, hevin) | ECM (serine protease inhibitor) | 4.0 |
| Zfp148 | Zinc finger protein 148 | Transcription factor (apoptosis regulation) | 2.7 |
| 2300003P22Rik | RIKEN cDNA 2300003P22 gene | Unknown | −4.7 |
| Cyp24a1 | Cytochrome P450, family 24, subfamily a, polypeptide 1 | Electron transport | −12.3 |
| Cyp2f2 | Cytochrome P450, family 2, subfamily f, polypeptide 2 | Electron transport | −4.3 |
| Expi | Extracellular proteinase inhibitor | proteinase inhibitor | −3.6 |
| Guca1a | Guanylate cyclase activator 1a (retina) | Calcium binding (photoreceptor activity) | −3.4 |
| Mknk2 | MAP kinase-interacting serine/threonine kinase 2 | Cell proliferation/differentiation | −3.1 |
| Npy | Neuropeptide Y | Cell migration, anti-angiogenic | −4.8 |
| Plac8 | Placenta-specific 8 | Immune response | −4.5 |
| Psca | Prostate stem cell antigen | Cell growth or immune response | −32.8 |
| Psmb8 | Proteosome (macropain) subunit, beta type 8 | Antigen processing | −3.4 |
| Rgs10 | Regulator of G-protein signalling 10 | Unknown | −2.6 |
| Xlr4 | X-linked lymphocyte-regulated 4 | Unknown | −4.0 |
*
Mean gene expression in P10/Adult cornea