Table 4.

Collaborative care interventions

Reference	Study Design	Depression Entry Criteria	M(SD) Baseline HbA1c levels	Enrolled/Completed	Treatment modality/Duration/Type	Depression Measures	Significant Depression Outcomes	Significant Health/Glucose Outcomes	Methodological Characteristics
Katon et al., 2004	RCT of collaborative case management, TAU	PHQ>=10 and HSCL-20 depression score>1.1	8.0 (1.6)% intervention group ,8.0 (1.5)% usual care group	329/288	Depression care management, pharmacotherapy or education/problem solving	HSCL-20	Patients in depression care management had less depression severity over time than those in TAU (z=2.84, p=.04)	No difference in HBA1c	RCT design with TAU comparison and 12-month follow-up, completer analyses, type 1 or 2, depressive symptoms, HbA1c outcome measure
Williams et al., 2004	RCT of depression care management, TAU	SCID MDD or Dysthymia	7.3 (1.3)% intervention group, 7.3 (1.5)% usual care group	417/350	Depression care management, pharmacotherapy or education/problem solving	HSCL-20	Depression care management patients had lower rate of depression (0.43 on 0-4 scale) than TAU	No difference in HBA1c	RCT design with TAU comparison and 12-month follow-up, ITT analyses, age 60 and over, type 1 and 2, MDD or dysthymia criterion, HbA1c outcome measure
Bogner et al., 2007	RCT of depression care management, TAU	SCID MDD CES-D>20	Not reported	123	Depression care management, pharmacotherapy or IPT	HDRS	Depression care management patients had lower rate of mortality than TAU patients (adjusted hazard ration 0.49%)	N/A	RCT design with TAU comparison and 5-year follow-up period, separate survival analyses on patients with diabetes from larger sample, age 60 and over, type 1 or 2, MDD or dysthymia criterion, no HbA1c measure or depression outcome