Table 3.
Effect of choline ± methionine deficiency on fatty acid flux measured by dilution of [13C4]palmitate tracer
| CS | CDD | MCDD | |
|---|---|---|---|
| Ra palmitate, μmol·kg−1·min−1 | 27.16 ± 3.46 | 26.25 ± 2.27 | 28.34 ± 3.46 |
| Fractional contribution to liver TG pool, % | 34.03 ± 5.11 | 11.38 ± 1.95*** | 14.56 ± 1.93*** |
| Liver TG pool, μmol/liver | 23.98 ± 3.69 | 51.27 ± 6.15** | 40.52 ± 4.58* |
| Absolute contribution to liver TG pool, μmol/liver | 6.88 ± 1.12 | 5.10 ± 0.87 | 5.83 ± 0.93 |
| Fractional contribution to plasma TG pool, % | 39.55 ± 5.25 | 28.80 ± 4.30 | 23.77 ± 5.23 |
| Plasma TG pool size, μmol | 0.67 ± 0.05 | 0.67 ± 0.06 | 0.46 ± 0.3*/† |
| Absolute contribution to plasma TG pool, μmol | 0.26 ± 0.04 | 0.19 ± 0.04 | 0.11 ± 0.03* |
Data are means ± SE, analyzed by 1-way ANOVA with Tukey's post hoc tests where appropriate.
P < 0.05,
P < 0.01, and
P < 0.001 vs. CS;
P < 0.05 vs. CDD; n = 12–15/group.