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A: pyruvate tolerance tests (PTT) were performed on 4-mo-old control and knockout mice (n = 6–8), and data are presented as areas under curve (AUC, artificial units). B: glucose tolerance tests (GTT) were performed on 2-mo-old control and knockout mice (n = 6–9). C: insulin tolerance tests (ITT) were performed on 2-mo-old control and knockout mice (n = 6–8). Values are presented as means ± SE. *P < 0.05 indicates a significant difference between DKOIrs1/2 and TKOIrs1/2:Sirt1 mice.
