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Neither nitric oxide (NO) nor prostacyclin upregulate PLGF mRNA expression. A: NO donor sodium nitroprusside (SNP) had no effect on PLGF gene expression at either 100 or 250 mM. n = 6 (vehicle, 100 μM), n = 3 (250 μM). P = NS for all (ANOVA on ranks). B: prostacyclin analog beraprost (100 nM) significantly inhibited PLGF gene expression relative to untreated cells (n = 6 for both groups). *P < 0.01 (ANOVA).
