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Signaling pathway of SST-mediated NHE8 activation in Caco-2 cells. Caco-2 cells were preincubated with H7 (10 μM), PD98059 (PD, 25 μM), and SB202190 (SB, 25 μM) for 1 h before addition of SST (1 μM). After 18 h, total protein was prepared from cells and used for Western blot analysis. Results are means ± SE from 3 to 5 experiments. *P < 0.01 for treatment vs. control. Bottom, corresponding Western blot image.
