Fig. 5.

Interaction between CCK-8 and leptin on nodose neuronal firing, and the effect of JMV-180 on this interaction. Intra-arterial infusion of CCK-8 (10 pmol) (A) did not stimulate vagal nodose neuronal firing. CCK-8 at 120 pmol (B) and leptin at 225 pmol (C) increased the neuronal discharge frequency. D: a synergistic effect was observed when CCK and leptin were infused together. E and F: administration of JMV-180 but not CCK-8 prevented this potentiation effect, which suggests that low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia.